Draxxin - Revision history

97.185.46.42 at 18:40, 17 August 2025

2025-08-17T18:40:49Z

← Older revision		Revision as of 18:40, 17 August 2025
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	~~Their is Officially no known on label treatment for~~ Pasteurella.		=Pasteurella Treatment in Rabbits=

	~~Off~~ label :		==Official Status==
			There is currently no FDA-approved, on-label treatment for Pasteurella multocida in rabbits.

	~~Draxin~~ appears to be the most effective treatment and ~~possible a~~ cure when ~~Pasteurella is~~ caught early. ~~Draxin given at~~ the first sign of sneezing ~~and~~ white ~~snot. appears~~ to ~~be effective in eliminating Pasteurella with~~ in ~~a 72 hour period~~. More trials are needed~~. Draxin was used in a piolet study~~ to ~~test it's effectiveness in rabbits in 2017~~.		==Off-Label Treatments==
			Draxxin (Tulathromycin) appears to be the most effective off-label treatment and may potentially cure Pasteurella when caught early. Early administration—at the first sign of sneezing or white nasal discharge—has been shown to eliminate the bacterium within approximately 72 hours in pilot studies. More trials are needed to confirm consistent efficacy.

	https://www.semanticscholar.org/paper/Efficacy-of-Tulathramycin-in-the-Treatment-of-in-Edrees-Abdellatief/be26b70bdee671eb3a4b0723e1a4a32409aef421?fbclid=IwAR214Q2aWv2GDy5WlLY4WWJjDIO4Sk8cLXY1UTSEEfdY2vp2dYxzle8u16A		A 2017 study by Edrees, Abdellatief, and El-Sharkawy evaluated the effectiveness of tulathromycin in experimentally infected rabbits:
	~~DOI:10.17582/JOURNAL.AAVS/~~2017~~/5.12.477.485Corpus ID: 80507273~~
	~~Efficacy of Tulathramycin in the Treatment of Respiratory Pasteurollosis in Rabbits~~
	N. Edrees, ~~Suhair A.~~ Abdellatief, ~~+1 author Amany~~ El-Sharkawy
	~~Published 1 November 2017 Medicine, Biology Advances in Animal and Veterinary Sciences~~
	~~\| Pasteurella multocida is the most critical respiratory bacterial infection of rabbits, around~~ the ~~globe. Beside passive immunization, anti-bacterial treatment is the primary choice~~ of ~~disease control. Since~~ tulathromycin ~~may be retained~~
	in the lung for many days after single administration, it can be applied for treatment of respiratory diseases. Hence, the purpose of current study was to evaluate the efficacy of tulathromycin in treating experimentally infected rabbits
	with P. multocida. In the sensitivity test, tulathromycin showed a potent inhibitory effect on P. multocida compared to several well-established antimicrobial agents. In vivo, treatment with tulathromycin improved clinical signs, mortality
	rate, lesion scores and growth performance parameters in infected rabbits. Furthermore, treatment with tulathromycin ameliorated the hematological picture, lowered the level of biochemical parameters which were significantly increased due
	to infection as liver enzymes, blood urea, creatinine and creatine kinase (CK-MB) and elevated the levels of total protein and albumin. Biochemical findings were supported by histopathological picture. It can be concluded that tulathromycin is an ideal and safe antibiotic for treating infection with Pasteurella multocida in rabbits

			* Edrees, N., Abdellatief, S.A., & El-Sharkawy, A. (2017). Efficacy of Tulathramycin in the Treatment of Respiratory Pasteurellosis in Rabbits. Advances in Animal and Veterinary Sciences, 5(12), 477–485. DOI: [10.17582/JOURNAL.AAVS/2017/5.12.477.485](https://www.semanticscholar.org/paper/Efficacy-of-Tulathramycin-in-the-Treatment-of-in-Edrees-Abdellatief/be26b70bdee671eb3a4b0723e1a4a32409aef421)

			The study concluded that tulathromycin significantly improved clinical signs, reduced mortality, improved growth performance, and normalized biochemical and hematological parameters in infected rabbits. Histopathology supported the observed improvements.

	~~We recently interviewed a veterinary zoologist and he~~ and Dr Carpenter ( ~~the~~ author of ~~the exotics formulary that all exotic vet use,~~ have ~~been trying~~ to ~~get~~ Draxxin ~~to be approved for on label treatment of Pasteurella~~ as a ~~black label~~ drug . ~~FDA is balking currently because rabbits~~ are meat animals ~~and the~~ dry off ~~time is min 60 days~~ , with 120 days ~~till butcher being~~ recommended~~, as a black~~ label ~~drug it can only be used in~~ pet ~~stock and stock~~ not intended for consumption.		==Regulatory Notes==
			Veterinary zoologists and Dr. James W. Carpenter (author of Exotic Animal Formulary) have attempted to gain FDA approval for Draxxin as a “black label” drug for Pasteurella in rabbits. However:

			* Rabbits are considered meat animals.
			* FDA requirements for meat stock: minimum 60-day dry-off, with 120 days recommended until slaughter.
			* Black-label use is therefore restricted to pet rabbits or rabbits not intended for consumption.

	Its not that it doesn't work its setting protocol FDA has been balking at		Its not that it doesn't work its setting protocol FDA has been balking at

96.94.236.94 at 16:49, 30 November 2023

2023-11-30T16:49:53Z

← Older revision		Revision as of 16:49, 30 November 2023
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	We did a barn trial on select cull rabbits to test it's effectiveness outside of a laboratory setting, and it had an approx 95% effective rate as a single dose on a 7 day trial. Rabbits that showed mild symptoms were given a follow up dose 7 days latter and all but 1 has full cleared. we would like to pursue a grant and full study to test this further in hope of getting Draxxin approved for on lable use.		We did a barn trial on select cull rabbits to test it's effectiveness outside of a laboratory setting, and it had an approx 95% effective rate as a single dose on a 7 day trial. Rabbits that showed mild symptoms were given a follow up dose 7 days latter and all but 1 has full cleared. we would like to pursue a grant and full study to test this further in hope of getting Draxxin approved for on lable use.




			http://www.veterinaryworld.org/Vol.5/July%202012/Pharmacokinetics%20and%20bioavailability%20of%20tulathromycin%20following%20IV,%20IM%20and%20SC%20administrations%20in%20healthy%20rabbits.pdf

96.94.236.94 at 16:39, 30 November 2023

2023-11-30T16:39:33Z

← Older revision		Revision as of 16:39, 30 November 2023
Line 15:		Line 15:
	rate, lesion scores and growth performance parameters in infected rabbits. Furthermore, treatment with tulathromycin ameliorated the hematological picture, lowered the level of biochemical parameters which were significantly increased due		rate, lesion scores and growth performance parameters in infected rabbits. Furthermore, treatment with tulathromycin ameliorated the hematological picture, lowered the level of biochemical parameters which were significantly increased due
	to infection as liver enzymes, blood urea, creatinine and creatine kinase (CK-MB) and elevated the levels of total protein and albumin. Biochemical findings were supported by histopathological picture. It can be concluded that tulathromycin is an ideal and safe antibiotic for treating infection with Pasteurella multocida in rabbits		to infection as liver enzymes, blood urea, creatinine and creatine kinase (CK-MB) and elevated the levels of total protein and albumin. Biochemical findings were supported by histopathological picture. It can be concluded that tulathromycin is an ideal and safe antibiotic for treating infection with Pasteurella multocida in rabbits



			We recently interviewed a veterinary zoologist and he and Dr Carpenter ( the author of the exotics formulary that all exotic vet use, have been trying to get Draxxin to be approved for on label treatment of Pasteurella as a black label drug . FDA is balking currently because rabbits are meat animals and the dry off time is min 60 days , with 120 days till butcher being recommended, as a black label drug it can only be used in pet stock and stock not intended for consumption.

			Its not that it doesn't work its setting protocol FDA has been balking at

	We did a barn trial on select cull rabbits to test it's effectiveness outside of a laboratory setting, and it had an approx 95% effective rate as a single dose on a 7 day trial. Rabbits that showed mild symptoms were given a follow up dose 7 days latter and all but 1 has full cleared. we would like to pursue a grant and full study to test this further in hope of getting Draxxin approved for on lable use.		We did a barn trial on select cull rabbits to test it's effectiveness outside of a laboratory setting, and it had an approx 95% effective rate as a single dose on a 7 day trial. Rabbits that showed mild symptoms were given a follow up dose 7 days latter and all but 1 has full cleared. we would like to pursue a grant and full study to test this further in hope of getting Draxxin approved for on lable use.

68.45.30.49: Created page with "Their is Officially no known on label treatment for Pasteurella. Off label : Draxin appears to be the most effective treatment and possible a cure when Pasteurella is caught early. Draxin given at the first sign of sneezing and white snot. appears to be effective in eliminating Pasteurella with in a 72 hour period. More trials are needed. Draxin was used in a piolet study to test it's effectiveness in rabbits in 2017. https://www.semanticscholar.org/paper/Efficacy..."

2023-08-02T21:37:22Z

Created page with "Their is Officially no known on label treatment for Pasteurella. Off label : Draxin appears to be the most effective treatment and possible a cure when Pasteurella is caught early. Draxin given at the first sign of sneezing and white snot. appears to be effective in eliminating Pasteurella with in a 72 hour period. More trials are needed. Draxin was used in a piolet study to test it's effectiveness in rabbits in 2017. https://www.semanticscholar.org/paper/Efficacy..."

New page

Their is Officially no known on label treatment for Pasteurella.

Off label :

Draxin appears to be the most effective treatment and possible a cure when Pasteurella is caught early. Draxin given at the first sign of sneezing and white snot. appears to be effective in eliminating Pasteurella with in a 72 hour period. More trials are needed. Draxin was used in a piolet study to test it's effectiveness in rabbits in 2017.

https://www.semanticscholar.org/paper/Efficacy-of-Tulathramycin-in-the-Treatment-of-in-Edrees-Abdellatief/be26b70bdee671eb3a4b0723e1a4a32409aef421?fbclid=IwAR214Q2aWv2GDy5WlLY4WWJjDIO4Sk8cLXY1UTSEEfdY2vp2dYxzle8u16A
DOI:10.17582/JOURNAL.AAVS/2017/5.12.477.485Corpus ID: 80507273
Efficacy of Tulathramycin in the Treatment of Respiratory Pasteurollosis in Rabbits
N. Edrees, Suhair A. Abdellatief, +1 author Amany El-Sharkawy
Published 1 November 2017 Medicine, Biology Advances in Animal and Veterinary Sciences
| Pasteurella multocida is the most critical respiratory bacterial infection of rabbits, around the globe. Beside passive immunization, anti-bacterial treatment is the primary choice of disease control. Since tulathromycin may be retained
in the lung for many days after single administration, it can be applied for treatment of respiratory diseases. Hence, the purpose of current study was to evaluate the efficacy of tulathromycin in treating experimentally infected rabbits
with P. multocida. In the sensitivity test, tulathromycin showed a potent inhibitory effect on P. multocida compared to several well-established antimicrobial agents. In vivo, treatment with tulathromycin improved clinical signs, mortality
rate, lesion scores and growth performance parameters in infected rabbits. Furthermore, treatment with tulathromycin ameliorated the hematological picture, lowered the level of biochemical parameters which were significantly increased due
to infection as liver enzymes, blood urea, creatinine and creatine kinase (CK-MB) and elevated the levels of total protein and albumin. Biochemical findings were supported by histopathological picture. It can be concluded that tulathromycin is an ideal and safe antibiotic for treating infection with Pasteurella multocida in rabbits

We did a barn trial on select cull rabbits to test it's effectiveness outside of a laboratory setting, and it had an approx 95% effective rate as a single dose on a 7 day trial. Rabbits that showed mild symptoms were given a follow up dose 7 days latter and all but 1 has full cleared. we would like to pursue a grant and full study to test this further in hope of getting Draxxin approved for on lable use.