Antimicrobial Agents

A

• Amikacin

2-5 mg/kg SC, IM q8-12h 8-16 mg/kg SC, IM, IV q24h

Decreased toxicity when given once daily; for IV use, dilute in 4 mL/kg saline and give over 20 min

10 mg/kg SC, IM q8-12h6 1.25 g/20 g methyl methacrylate Place in bone after surgical debridement of jaw abscess

• Azithromycin

C

• Cefazolin
• Cefotaxime
• Ceftazidime
• Ceftiofur
• Ceftriaxone (Rocephin, Roche)
• Cephalexin
• Cephalothin
• Chloramphenicol
• Chlortetracycline
• Ciprofloxacinb (Cipro, Bayer; Ciloxan, Alcon)

D

Difloxacinb (Dicural,Fort Dodge): PD; dose appropriate for E. coli infections

5 mg/kg IM, IV q24h

Doxycycline

2.5 mg/kg PO q12h
4 mg/kg PO q24h

E

Enrofloxacinb (Baytril,Bayer)

F

Florfenicol Furazolidone

G

Gentamicin

M

Marbofloxacin Metronidazole Minocycline Moxifloxacin

N

Netilmicin (Netromycin,Schering) For IV use, dilute and give over 20 min

6-8 mg/kg SC, IM, IV q24h

O

Ofloxacinb (Ocuflox,Allergan) Urogenital, skin, respiratory infections

20 mg/kg SC q8h

Oxytetracycline: PD; anorexia and diarrhea at 30 mg/kg, IM q8h; tissue irritation can occur.

15 mg/kg IM q8h
25 mg/kg SC q24h
50 mg/kg PO q12h
1 mg/mL drinking water

P

Penicillin G : Do not give any form of penicillin orally to rabbits

      Benzathine form  
      Benzathine penicillin achieves lower serum levels than other forms and is effective 
      against only highly susceptible organisms
      42,000-60,000 U/kg IM q48h |   42,000-84,000 U/kg SC q7d x 3 wk

      Procaine  form : Rabbit syphilis
      40,000 U/kg IM q24h 3 5-7 days |  42,000-84,000 U/kg SC, IM q24h | 60,000 U/kg IM q8h

R

Rifampin (R)/azithromycin (A): Staphylococcus osteomyelitis

Rifampin (R)/clarithromycin (C): Staphylococcus osteomyelitis

S

Silver sulfadiazine cream (Silvadene,Marion): Does not cause diarrhea if ingested

Sulfadimethoxine

Sulfamethazine

Sulfaquinoxaline

T

Tetracycline: Therapeutic levels not achieved even at 800-1600 mg/L;139 250 mg/L not effective in clinical trial for pasteurellosis

50 mg/kg PO q8-12h
50-100 mg/kg PO q8h
250-1000 mg/L drinking water

Tilmicosin (Micotil, Elanco)

Tobramycin (Nebcin,Lilly) : Pasteurellosis; use cautiously: at least one rabbit death and several human deaths have been reported; has been associated with anemia and leukopenia

Trimethoprim/sulfa : May cause tissue necrosis when given SC

Tylosin (Tylan, Elanco)

V

Vancomycin