Toltrazuril5:

Treatment for Coccidia infestation, Toltrazuril (Baycox®) should be used in more advanced cases as it will completely eradicate the parasites'.

Symptoms of Coccidia are:

• Depression
• Anorexia
• Anemia
• Signs of pain such as hunching
• Pale mucous membranes
• Blood or mucous in the feces
• Poor coat condition
• Dehydration
• Weight loss or poor weight gainor growth
• In severe cases of intestinal coccidiosis intussusception, convulsions or paralysis or fatality may occur
• In severe cases of hepatic coccidiosis weakness, liver damage, and bile duct damage may occur, followed by coma

Drug class:

Antiprotozoal/Anticoccidial Agent

https://file.medchemexpress.com/batch_PDF/HY-B0175/Toltrazuril-DataSheet-MedChemExpress.pdf https://cdn.brief.vet/web-files/PVD/drupal-uploads/files/VMG-Toltrazuril-2019-01-30-0421.pdf https://www.drugs.com/vet/baycox-toltrazuril-5-oral-suspension-can.html

Dose:

Dosage is 20mg/kg. Concentration is 5% or 50mg / mL which is equivalent to approximately .18ml/cc per pound. https://www.vgr1.com/toltrazuril/ dosage calculator

Indications:

Used to treat certain types of protozoal infections. Not currently available in the US, but may be legally imported by a veterinarian. May be given either with food or on an empty stomach. If your animal vomits or acts sick after receiving the drug on an empty stomach, try giving the next dose with food or a small treat. If vomiting continues, contact your veterinarian. Avoid direct contact with the medication; wear disposable gloves and wash hands after giving medication. Appears to be well tolerated by many species of animals.

Side Effects

Side effects that usually are not serious include: Stomach upset, vomiting, and diarrhea. You don’t have to be overly concerned if you see any of these signs unless they are severe, worsen, or continue to be a problem. Contact your veterinarian if this happens.

Drug Interactions

This drug SHOULD NOT be used in patients: That are allergic to it or drugs like it(eg, ponazuril).

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Toltrazuril (Baycox) treatment against coccidiosis https://pubmed.ncbi.nlm.nih.gov/25286655/

Evaluation of amprolium and toltrazuril efficacy in controlling natural intestinal rabbit coccidiosis https://pubmed.ncbi.nlm.nih.gov/29163644/

Plasma disposition of toltrazuril and its metabolites, toltrazuril sulfoxide and toltrazuril sulfone, in rabbits after oral administration https://pubmed.ncbi.nlm.nih.gov/20083354/

Eimeria stiedae: experimental infection in rabbits and the effect of treatment with toltrazuril and ivermectin https://pubmed.ncbi.nlm.nih.gov/18321485/

Pharmacokinetics of toltrazuril and its metabolites after oral and parenteral administration of novel oil-based suspension based on micro-environmental pH-modifying solid dispersion in rabbits https://pubmed.ncbi.nlm.nih.gov/34597913/

Toltrazuril mixed nanomicelle delivery system based on sodium deoxycholate-Brij C20 polyethylene ether-triton x100: Characterization, solubility, and bioavailability study https://pubmed.ncbi.nlm.nih.gov/29289823/

Comparison of toltrazuril and sulphadimethoxine in the treatment of intestinal coccidiosis in pet rabbits https://pubmed.ncbi.nlm.nih.gov/20729515/

The production and characterisation of an antibody to detect the coccidiostat toltrazuril and its metabolite ponazuril https://pubmed.ncbi.nlm.nih.gov/12790197/

Pharmacokinetics and improved bioavailability of toltrazuril after oral administration to rabbits https://pubmed.ncbi.nlm.nih.gov/20860101/

Herbal formulations as feed additives in the course of rabbit subclinical coccidiosis https://pubmed.ncbi.nlm.nih.gov/24930248/