Editing Baytril


This antibiotic is widely used in veterinary medicine as an antibacterial agent, showing high activity against both Gram-negative and Gram-positive bacteria
Enrofloxacin, sold under the brand name Baytril, among others, is a fluoroquinolone antibiotic used for the treatment of animals. It is a bactericidal agent. The bactericidal activity of enrofloxacin is concentration-dependent, with susceptible bacteria cell death occurring within 20–30 minutes of exposure. 



*Pregnancy category: AU: B3
*Metabolism: Kidney and non-kidney
*Excretion: Bile duct (70%); kidney (30%)
*AHFS/Drugs.com: International Drug Names
*ATCvet code: QJ01MA90 (WHO) QD06BA51 (WHO)
*Bioavailability: 80% in dogs, 65-75% in sheep
*Elimination half-life: 4–5 hours in dogs, 6 hours in cats, 1.5 - 4.5 hours in sheep
*Antimicrobial Agents Used in Rabbits



== Enrofloxacin uses and doses in Rabbits==


===Pasteurella Protocol ===
as been use for  Pasteurella and respiratory issues, it more frequently masks of Pasteurella symptoms then cures. Baytril is a Broad spectrum Antibiotic so can be used to treat a wide range of issues, it is stronger then LA 200. 
Broome RL, Brooks DL. Efficacy of enrofloxacin in the treatment of respiratory pasteurellosis in rabbits. Lab Anim Sci 1991;41:572-576.



===GI stasis protocol===
•	Use only when indicated; enrofloxacin or trimethoprim/sulfa are generally the drugs of choice; use parenterally until stools are passed; metronidazole may be indicated for anaerobe overgrowth

*Broome RL, Brooks DL, Babish JG, et al. Pharmacokinetic properties of enrofloxacin in rabbits. Am J Vet Res 1991;52:1835-1841.
*Cabanes A, Arboix M, Anton JMG, et al. Pharmacokinetics of enrofloxacin after intravenous and intramuscular injection in rabbits. Am J Vet Res 1992;53:2090-2093.
*Elmas M, Uney K, Yazar E, et al. Pharmacokinetics of enrofloxacin following intravenous and intramuscular administration in Angora rabbits. Res Vet Sci 2007;82:242-245.

==Drug class:== 




==Dose:==
Enrofloxacinb (Baytril, Bayer)   

Dosage:

200 mg/L drinking water  14 days

5 mg/kg IM, IV q12-24h44       Angora rabbits/PD

5 mg/kg PO, SC, IM, IV  PD;19,23 clinical trial for pasteurellosis,  14 days

5-10 mg/kg PO, SC, IM q12h  Pasteurellosis

5-20 mg/kg PO, IM q12h 3 14-30 days     Pasteurellosis

==Indications:==


==Side Effects==


==During Pregnancy or Nursing==
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==Patient Tips==

==Drug Interactions==

==Compare Alternatives==


==notes==
May cause arthropathies in young dogs, but similar effects using standard dosages in rabbits have not been reported; SC and IM injections may cause muscle necrosis or sterile abscesses; dilute before giving parenterally






==References==
Exotic animal formulary / editor, James W. Carpenter ; associate editor, Christopher J. Marion. -- 4th ed.  p. ; cm. 
ISBN 978-1-4377-2264-2 (pbk.) I. Carpenter, James W. (James Wyman). II. Marion, Christopher J. 
[DNLM: 1. Veterinary Drugs--Formularies. 2. Animals, Domestic--Formularies. 3. Animals,  Wild--Formularies. 4. Animals, Zoo--Formularies. 5. Drug Therapy--veterinary--Formularies. SF 917]
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 as been use for  Pasteurella and respiratory issues, it more frequently masks of Pasteurella symptoms then cures. Baytril is a Broad spectrum Antibiotic so can be used to treat a wide range of issues, it is stronger then LA 200.
 Broome RL, Brooks DL. Efficacy of enrofloxacin in the treatment of respiratory pasteurellosis in rabbits. Lab Anim Sci 1991;41:572-576.
-Baytril has also been effective to treat  early onset cases in trials 2014.
-https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-014-0276-6
-Alternative treatment of serious and mild Pasteurella multocida infection in New Zealand White rabbits
-Orsolya Palócz, János Gál, Paul Clayton, Zoltán Dinya, Zoltán Somogyi, Csaba Juhász & György Csikó
-BMC Veterinary Research volume 10, Article number: 276 (2014)
- Pasteurella multocida causes numerous economically relevant diseases in livestock including rabbits. Immunization is only variably effective. Prophylactic
- antibiotics are used in some species but are contra-indicated in rabbits, due to their adverse effects on the rabbit microbiota. There is therefore a substantial
- need for alternative forms of infection control in rabbits; we investigated the effect of oral β-glucan on P. multocida infection in this species.
- Results
- Thirty-five New Zealand White rabbits were randomly divided into five groups of seven animals. Three groups were inoculated with Pasteurella multocida
- intranasally (in.), a physiologically appropriate challenge which reproduces naturally acquired infection, and received either (1-3), (1-6) β-glucans or placebo.
- Four other groups were inoculated both in. and intramuscularly (im.), representing a supra-physiological challenge, and received either (1-3), (1-6) β-glucans,
- antibiotic or placebo. β-glucans given prophylactically were highly effective in protecting against physiological (in.) bacterial challenge. They were less
- effective in protecting against supra-physiological bacterial challenge (in. and im.), although they extended survival times. This latter finding has practical
- relevance to breeders as it extends the window in which heavily infected and symptomatic animals can be salvaged with antibiotics.
- Conclusions
- In our study, (1-3), (1-6) β-glucans were highly effective in protecting against a model of naturally acquired P. multocida infection and extended survival times
- in the supra-physiological model. Enrofloxacin(baytril) was effective in protecting against supra-physiological infection. We are currently reviewing the use of combined
- prophylaxis.