Difference between revisions of "Mutations"

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= Genetic Mutations & Oddities =


A case of combined hermaphroditism and autofertilisation in a domestic rabbit
== Hermaphroditism and Autofertility ==
M T Frankenhuis et al. Vet Rec. 1990.
* **Frankenhuis et al., 1990** – "A case of combined hermaphroditism and autofertilisation in a domestic rabbit." 
https://pubmed.ncbi.nlm.nih.gov/2382355/
  * Vet Rec.
  * [PubMed link](https://pubmed.ncbi.nlm.nih.gov/2382355/)


* **Sheppard, 1943** – "The reproductive system of a pregnant hermaphrodite rabbit (Oryctolagus cuniculus)." 
  * J Anat. 77(Pt 4): 288–293 
  * [PMC link](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1252732/)


* **Bayraktar, 2017** – "Potential autofertility in true hermaphrodites." 
  * Journal of Maternal-Fetal & Neonatal Medicine 31(4):1–10 
  * DOI:10.1080/14767058.2017.1291619 
  * [ResearchGate link](https://www.researchgate.net/publication/313454996_Potential_autofertility_in_true_hermaphrodites)


‐-------
== Broken Pattern Oddities ==
* Occasionally, a rabbit may present with a single random white spot (e.g., on the foot). While injury is a likely cause in many cases, the broken gene can sometimes be expressed so subtly that only one hair appears white. 


J Anat. 1943 Jul; 77(Pt 4): 288–293.   
* Key points about Broken patterns: 
PMCID: PMC1252732PMID: 17104934
  * Broken is **not** a white rabbit with black patches; it is a **solid-colored rabbit with a white overlay**.   
The reproductive system of a pregnant hermaphrodite rabbit (Oryctolagus cuniculus)
  * White is a stripping effect caused by genes that block or dilute the density of eumelanin and pheomelanin. 
E. M. Sheppard
  * To confirm a rabbit is genetically broken, **test breeding** is required.


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1252732/
* Genes and combinations that can produce broken patterns, random spotting, or “leakage”:
  * `En` – Broken 
  * `aachdchd` – Self homozygous Chinchilla 
  * `v` – Vienna 
  * `duw, dud` – Dutch variants 
  * Chimera / somatic gene mutation – genes copied incorrectly during cell division 


 
* [PMC article on gene mutations affecting pigmentation](https://pmc.ncbi.nlm.nih.gov/articles/PMC3695642/)
-----
Potential autofertility in true hermaphrodites
February 2017The Journal of Maternal-Fetal & Neonatal Medicine 31(4):1-10
DOI:10.1080/14767058.2017.1291619
Authors:
Zeki Bayarktar
Istanbul Medipol University
 
https://www.researchgate.net/publication/313454996_Potential_autofertility_in_true_hermaphrodites
 
 
 
 
 
 
 
On broken patterning oddities rabbit presented with one random  white spot on top of foot.
although in this case  injury is most likely. Broken pattern can be so heavily  marked that it may only show as a single white hair. You will only know with a test breeding if she is genetically broken.
 
Also broken is not a white with black.its the opposite.  Its a solid color rabbit with a white blanket on it. Much like for cc REW , are colored rabbits with a giant white spot.  When you see with on any animal its because the color has been masked by the genes blocking then from showing .  White is a stripping  effect.
 
So what the genes do to produce white is block , or dilute the density of eumelanin and pheomelanin.
 
Genes and combo  that can produce broken patterns , random spotting  or leakage are  :
En-  broken
aachdchd- self homozygous chinchilla
v- Vienna
duw,dud -dutch
Or chimera,  somatic gene mutation where genes copied incorrectly durring transfer
 
 
 
 
https://pmc.ncbi.nlm.nih.gov/articles/PMC3695642/

Latest revision as of 18:38, 16 August 2025

Genetic Mutations & Oddities[edit | edit source]

Hermaphroditism and Autofertility[edit | edit source]

  • **Frankenhuis et al., 1990** – "A case of combined hermaphroditism and autofertilisation in a domestic rabbit."
 * Vet Rec.  
 * [PubMed link](https://pubmed.ncbi.nlm.nih.gov/2382355/)
  • **Sheppard, 1943** – "The reproductive system of a pregnant hermaphrodite rabbit (Oryctolagus cuniculus)."
 * J Anat. 77(Pt 4): 288–293  
 * [PMC link](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1252732/)
  • **Bayraktar, 2017** – "Potential autofertility in true hermaphrodites."
 * Journal of Maternal-Fetal & Neonatal Medicine 31(4):1–10  
 * DOI:10.1080/14767058.2017.1291619  
 * [ResearchGate link](https://www.researchgate.net/publication/313454996_Potential_autofertility_in_true_hermaphrodites)

Broken Pattern Oddities[edit | edit source]

  • Occasionally, a rabbit may present with a single random white spot (e.g., on the foot). While injury is a likely cause in many cases, the broken gene can sometimes be expressed so subtly that only one hair appears white.
  • Key points about Broken patterns:
 * Broken is **not** a white rabbit with black patches; it is a **solid-colored rabbit with a white overlay**.  
 * White is a stripping effect caused by genes that block or dilute the density of eumelanin and pheomelanin.  
 * To confirm a rabbit is genetically broken, **test breeding** is required.
  • Genes and combinations that can produce broken patterns, random spotting, or “leakage”:
 * `En` – Broken  
 * `aachdchd` – Self homozygous Chinchilla  
 * `v` – Vienna  
 * `duw, dud` – Dutch variants  
 * Chimera / somatic gene mutation – genes copied incorrectly during cell division
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