Difference between revisions of "Genetics"

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the science and study of the gene that make up the codeing  of a living  thing.
= Rabbit Genetics =


Topics:
'''Overview:''' Genetics is the science and study of the genes that make up the coding of living organisms. Rabbits serve as valuable models for studying genetic traits, coat colors, growth, and disease.
* [[https://mmcrabbits.com/BCWiki/index.php/Basic_Color_Genetics Basic Color Genetics]]
* [[https://mmcrabbits.com/BCWiki/index.php/Advanced_Color_Genetics Advanced Color Genetics]]
* [[https://mmcrabbits.com/BCWiki/index.php/Coat_Genetics Coat Genetics ]]
* [[https://mmcrabbits.com/BCWiki/index.php/Traits Traits]]
* [[https://mmcrabbits.com/BCWiki/index.php/Genetic_Health_Defects Genetic Health Defects]]
* [[https://mmcrabbits.com/BCWiki/index.php/Mutations Mutations]]


Rabbit Color by Phenotype
== Topics ==
* [[https://mmcrabbits.com/BCWiki/index.php/Basic_Color_Genetics|Basic Color Genetics]]
* [[https://mmcrabbits.com/BCWiki/index.php/Advanced_Color_Genetics|Advanced Color Genetics]]
* [[https://mmcrabbits.com/BCWiki/index.php/Coat_Genetics|Coat Genetics]]
* [[https://mmcrabbits.com/BCWiki/index.php/Traits|Traits]]
* [[https://mmcrabbits.com/BCWiki/index.php/Genetic_Health_Defects|Genetic Health Defects]]
* [[https://mmcrabbits.com/BCWiki/index.php/Mutations|Mutations]]


== Rabbit Color by Phenotype ==
Details and links for rabbit coat color phenotypes can be found in the pages above.


== Key Research and References ==


=== Genetic Testing Services ===
* [https://www.creative-biolabs.com/car-t/rabbit-rla-genotyping-service.htm Rabbit RLA Genotyping Service]


=== Genomic Studies and Databases ===
* Fontanesi, L. (2021). ''Rabbit Genetic Resources Can Provide Several Animal Models to Explain Morphological and Physiological Traits''. Appl. Sci. 11(1), 373. [https://www.mdpi.com/2076-3417/11/1/373 Full text]
* Zhou, L., et al. (2018). ''RabGTD: a comprehensive database of rabbit genome and transcriptome''. Database, 2018, bay075. [https://academic.oup.com/database/article/doi/10.1093/database/bay075/5053987 Full text]
* Oryctolagus cuniculus breed Thorbecke inbred, whole genome shotgun sequencing project: [https://www.ncbi.nlm.nih.gov/nuccore/256946799 NCBI]


=== Coat Color Genetics ===
* Bychkova, E., et al. (2020). ''Identification of a candidate genetic variant for the Himalayan color pattern in dogs''. [https://pubmed.ncbi.nlm.nih.gov/33039541/ PubMed]
* Introduction to coat color genetics – [https://youtu.be/UhKouNuw6_k YouTube: Dr. Steve Roush]
* Advanced coat color genetics – [https://youtu.be/0MFx6q3Qka8 YouTube: Dr. Steve Roush]
* Oregon State University: [https://extension.oregonstate.edu/gallery/rabbit-coat-color-genetics-gallery Coat Color Genetics Gallery]
* OR Extension: [https://extension.oregonstate.edu/animals-livestock/poultry-rabbits/understanding-genetics-behind-rabbit-coat-colors-part-2-coat Part 2 – Coat Colors]
* [https://thenaturetrail.com/rabbit-genetics/color-e-extension-series-steel-tricolor-locus/ Steel & Tricolor Locus]


Unsorted links
=== Genomic Diversity and Selection ===
* Ballan, M., et al. (2022). ''Genomic diversity and signatures of selection in meat and fancy rabbit breeds''. [https://pubmed.ncbi.nlm.nih.gov/35062866 PubMed]
* Ballan, M., et al. (2023). ''Population genomic structures and signatures of selection define the genetic uniqueness of several fancy and meat rabbit breeds''. [https://pubmed.ncbi.nlm.nih.gov/37435689 PubMed]
* Bovo, S., et al. (2023). ''Genome-wide association studies for diarrhoea outcomes in suckling rabbits''. [https://pubmed.ncbi.nlm.nih.gov/38152994 PubMed]


=== Gene-Specific Research ===
* Demars, J., et al. (2018). ''Melanophilin (MLPH) gene affecting coat color dilution''. [https://pubmed.ncbi.nlm.nih.gov/30142960 PubMed]
* Fontanesi, L., et al. (2009). ''Agouti signaling protein (ASIP) gene characterization and nonagouti black coat color mutation''. [https://pubmed.ncbi.nlm.nih.gov/20004240 PubMed]
* Fontanesi, L., et al. (2014). ''KIT gene and English spotting locus, congenital megacolon in Checkered Giant rabbits''. [https://pubmed.ncbi.nlm.nih.gov/24736498 PubMed]


https://www.creative-biolabs.com/car-t/rabbit-rla-genotyping-service.htm. testing?
=== Growth and Production Traits ===
* Fontanesi, L., et al. (2013). ''MC4R gene associated with finishing weight in a meat rabbit line''. [https://pubmed.ncbi.nlm.nih.gov/23947663 PubMed]
* Fontanesi, L., et al. (2015). ''Growth Hormone Receptor (GHR) polymorphisms and finishing weight''. [https://pubmed.ncbi.nlm.nih.gov/26913548 PubMed]
* Sosa-Madrid, B., et al. (2019). ''GWAS in divergently selected lines reveals genomic regions for litter size''. [https://pubmed.ncbi.nlm.nih.gov/31657065 PubMed]


=== General Rabbit Genomics ===
* Miller, I., et al. (2014). ''The rabbit as an experimental and production animal: from genomics to proteomics''. [https://pubmed.ncbi.nlm.nih.gov/24555894 PubMed]
* Biro, B., et al. (2022). ''Nuclear mitochondrial DNA sequences in the rabbit genome''. [https://pubmed.ncbi.nlm.nih.gov/35842180 PubMed]
* Rabbit models overview: [https://pmc.ncbi.nlm.nih.gov/articles/PMC9501708/ PMC]


Rabbit Genetic Resources Can Provide Several Animal Models to Explain at the Genetic Level the Diversity of Morphological and Physiological Relevant Traits
== See Also ==
by Luca FontanesiORCID
* [[Basic Color Genetics]]
Department of Agricultural and Food Sciences, Division of Animal Sciences, University of Bologna, Viale Giuseppe Fanin 46, 40127 Bologna, Italy
* [[Advanced Color Genetics]]
Appl. Sci. 2021, 11(1), 373; https://doi.org/10.3390/app11010373
* [[Coat Genetics]]
Received: 6 December 2020 / Revised: 27 December 2020 / Accepted: 28 December 2020 / Published: 2 January 2021
* [[Traits]]
https://www.mdpi.com/2076-3417/11/1/373
* [[Mutations]]
 
* [[Genetic Health Defects]]
 
 
 
Identification of a candidate genetic variant for the Himalayan color pattern in dogs
Elina Bychkova 1, Olga Viktorovskaya 2, Elizaveta Filippova 3, Zhanna Eliseeva 4, Larisa Barabanova 4, Maria Sotskaya 5, Anton Markov 3
Affiliations expand
PMID: 33039541 DOI: 10.1016/j.gene.2020.145212
https://pubmed.ncbi.nlm.nih.gov/33039541/#:~:text=Himalayan%20color%20is%20genetically%20determined,as%20the%20tyrosinase%20gene%20TYR.
 
 
 
https://youtu.be/UhKouNuw6_k introduction to coat color genetics. DR Steve Roush
 
 
https://youtu.be/0MFx6q3Qka8  Advanced coat color genetics by Dr Steve Roush
 
 
Oryctolagus cuniculus breed Thorbecke inbred, whole genome shotgun sequencing project
https://www.ncbi.nlm.nih.gov/nuccore/256946799
 
RabGTD: a comprehensive database of rabbit genome and transcriptome
Lu Zhou, Qingyu Xiao, Jie Bi, Zhen Wang, Yixue Li Author Notes
Database, Volume 2018, 2018, bay075, https://doi.org/10.1093/database/bay075
https://academic.oup.com/database/article/doi/10.1093/database/bay075/5053987?login=false
 
 
https://extension.oregonstate.edu/gallery/rabbit-coat-color-genetics-gallery
 
https://extension.oregonstate.edu/animals-livestock/poultry-rabbits/understanding-genetics-behind-rabbit-coat-colors-part-2-coat
 
https://thenaturetrail.com/rabbit-genetics/color-e-extension-series-steel-tricolor-locus/
 
https://www.frontiersin.org/articles/10.3389/fgene.2019.00875/full
https://www.mdpi.com/2076-3417/11/1/373/htm
 
https://extension.oregonstate.edu/animals-livestock/poultry-rabbits/rabbit-coat-color-genetics-summary-table
 
 
 
 
Genome-wide association studies for diarrhoea outcomes identified genomic regions affecting resistance to a severe enteropathy in suckling rabbits
Samuele Bovo 1, Anisa Ribani 1, Giuseppina Schiavo 1, Valeria Taurisano 1, Francesca Bertolini 1, Daniela Fornasini 2, Andrea Frabetti 2, Luca Fontanesi 1
Affiliations Expand
PMID: 38152994 DOI: 10.1111/jbg.1284
https://pubmed.ncbi.nlm.nih.gov/38152994/
 
 
 
New Insights into the Melanophilin (MLPH) Gene Affecting Coat Color Dilution in Rabbits
Julie Demars 1, Nathalie Iannuccelli 2, Valerio Joe Utzeri 3, Gerard Auvinet 4, Juliette Riquet 5, Luca Fontanesi 6, Daniel Allain 7
Affiliations Expand
PMID: 30142960 PMCID: PMC6162760 DOI: 10.3390/genes9090430
https://pubmed.ncbi.nlm.nih.gov/30142960/
 
 
 
Population genomic structures and signatures of selection define the genetic uniqueness of several fancy and meat rabbit breeds
Mohamad Ballan 1, Samuele Bovo 1, Francesca Bertolini 1, Giuseppina Schiavo 1, Michele Schiavitto 2, Riccardo Negrini 3, Luca Fontanesi 1
Affiliations Expand
PMID: 37435689 DOI: 10.1111/jbg.12818
https://pubmed.ncbi.nlm.nih.gov/37435689/
 
 
Genomic diversity and signatures of selection in meat and fancy rabbit breeds based on high-density marker data
Mohamad Ballan # 1, Samuele Bovo # 1, Giuseppina Schiavo 1, Michele Schiavitto 2, Riccardo Negrini 3, Luca Fontanesi 4
Affiliations Expand
PMID: 35062866 PMCID: PMC8780294 DOI: 10.1186/s12711-022-00696-9
https://pubmed.ncbi.nlm.nih.gov/35062866/
 
 
 
The TBC1D1 gene: structure, function, and association with obesity and related traits
Luca Fontanesi 1, Francesca Bertolini
Affiliations Expand
PMID: 23374713 DOI: 10.1016/B978-0-12-407766-9.00004-3
https://pubmed.ncbi.nlm.nih.gov/23374713/
 
 
 
Nuclear mitochondrial DNA sequences in the rabbit genome
Bálint Biró 1, Zoltán Gál 1, Giuseppina Schiavo 2, Anisa Ribari 2, Valerio Joe Utzeri 2, Michael Brookman 3, Luca Fontanesi 2, Orsolya Ivett Hoffmann 4
Affiliations Expand
PMID: 35842180 DOI: 10.1016/j.mito.2022.07.003
https://pubmed.ncbi.nlm.nih.gov/35842180/
 
 
The rabbit as an experimental and production animal: from genomics to proteomics
Ingrid Miller, Claire Rogel-Gaillard, Domenico Spina, Luca Fontanesi, Andre M de Almeida 1
Affiliations Expand
PMID: 24555894 DOI: 10.2174/1389203715666140221115135
https://pubmed.ncbi.nlm.nih.gov/24555894/
 
 
 
A genome-wide association study in divergently selected lines in rabbits reveals novel genomic regions associated with litter size traits
Bolívar Samuel Sosa-Madrid 1, María Antonia Santacreu 1, Agustín Blasco 1, Luca Fontanesi 2, Romi Natacha Pena 3, Noelia Ibáñez-Escriche 1
Affiliations Expand
PMID: 31657065 DOI: 10.1111/jbg.12451
https://pubmed.ncbi.nlm.nih.gov/31657065/
 
 
Characterization of the rabbit agouti signaling protein (ASIP) gene: transcripts and phylogenetic analyses and identification of the causative mutation of the nonagouti black coat colour
Luca Fontanesi 1, Lionel Forestier, Daniel Allain, Emilio Scotti, Francesca Beretti, Séverine Deretz-Picoulet, Elena Pecchioli, Cristiano Vernesi, Terence J Robinson, Jason L Malaney, Vincenzo Russo, Ahmad Oulmouden
Affiliations Expand
PMID: 20004240 DOI: 10.1016/j.ygeno.2009.11.003
https://pubmed.ncbi.nlm.nih.gov/20004240/
 
 
The KIT gene is associated with the english spotting coat color locus and congenital megacolon in Checkered Giant rabbits (Oryctolagus cuniculus)
Luca Fontanesi 1, Manuela Vargiolu 2, Emilio Scotti 3, Rocco Latorre 4, Maria Simonetta Faussone Pellegrini 5, Maurizio Mazzoni 6, Martina Asti 6, Roberto Chiocchetti 6, Giovanni Romeo 7, Paolo Clavenzani 6, Roberto De Giorgio 8
Affiliations Expand
PMID: 24736498 PMCID: PMC3988019 DOI: 10.1371/journal.pone.0093750
https://pubmed.ncbi.nlm.nih.gov/24736498/
 
 
A missense mutation in the rabbit melanocortin 4 receptor (MC4R) gene is associated with finishing weight in a meat rabbit line
Luca Fontanesi 1, Emilio Scotti, Katarina Cisarova, Piero Di Battista, Stefania Dall'olio, Daniela Fornasini, Andrea Frabetti
Affiliations Expand
PMID: 23947663 DOI: 10.1080/10495398.2013.781034
https://pubmed.ncbi.nlm.nih.gov/23947663/
 
Identification of Polymorphisms in the Rabbit Growth Hormone Receptor (GHR) Gene and Association with Finishing Weight in a Commercial Meat Rabbit Line
Luca Fontanesi 1, Giuseppe Sparacino 1, Valerio Joe Utzeri 1, Emilio Scotti 1, Daniela Fornasini 2, Stefania Dall'Olio 1, Andrea Frabetti 2
Affiliations Expand
PMID: 26913548 DOI: 10.1080/10495398.2015.1101697
https://pubmed.ncbi.nlm.nih.gov/26913548/
 
 
 
 
Rabbit models.
 
https://pmc.ncbi.nlm.nih.gov/articles/PMC9501708/

Latest revision as of 18:35, 16 August 2025

Rabbit Genetics[edit | edit source]

Overview: Genetics is the science and study of the genes that make up the coding of living organisms. Rabbits serve as valuable models for studying genetic traits, coat colors, growth, and disease.

Topics[edit | edit source]

Rabbit Color by Phenotype[edit | edit source]

Details and links for rabbit coat color phenotypes can be found in the pages above.

Key Research and References[edit | edit source]

Genetic Testing Services[edit | edit source]

Genomic Studies and Databases[edit | edit source]

  • Fontanesi, L. (2021). Rabbit Genetic Resources Can Provide Several Animal Models to Explain Morphological and Physiological Traits. Appl. Sci. 11(1), 373. Full text
  • Zhou, L., et al. (2018). RabGTD: a comprehensive database of rabbit genome and transcriptome. Database, 2018, bay075. Full text
  • Oryctolagus cuniculus breed Thorbecke inbred, whole genome shotgun sequencing project: NCBI

Coat Color Genetics[edit | edit source]

Genomic Diversity and Selection[edit | edit source]

  • Ballan, M., et al. (2022). Genomic diversity and signatures of selection in meat and fancy rabbit breeds. PubMed
  • Ballan, M., et al. (2023). Population genomic structures and signatures of selection define the genetic uniqueness of several fancy and meat rabbit breeds. PubMed
  • Bovo, S., et al. (2023). Genome-wide association studies for diarrhoea outcomes in suckling rabbits. PubMed

Gene-Specific Research[edit | edit source]

  • Demars, J., et al. (2018). Melanophilin (MLPH) gene affecting coat color dilution. PubMed
  • Fontanesi, L., et al. (2009). Agouti signaling protein (ASIP) gene characterization and nonagouti black coat color mutation. PubMed
  • Fontanesi, L., et al. (2014). KIT gene and English spotting locus, congenital megacolon in Checkered Giant rabbits. PubMed

Growth and Production Traits[edit | edit source]

  • Fontanesi, L., et al. (2013). MC4R gene associated with finishing weight in a meat rabbit line. PubMed
  • Fontanesi, L., et al. (2015). Growth Hormone Receptor (GHR) polymorphisms and finishing weight. PubMed
  • Sosa-Madrid, B., et al. (2019). GWAS in divergently selected lines reveals genomic regions for litter size. PubMed

General Rabbit Genomics[edit | edit source]

  • Miller, I., et al. (2014). The rabbit as an experimental and production animal: from genomics to proteomics. PubMed
  • Biro, B., et al. (2022). Nuclear mitochondrial DNA sequences in the rabbit genome. PubMed
  • Rabbit models overview: PMC

See Also[edit | edit source]

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